Diagnostic Criteria for Acute Destructive Pancreatitis

The relevance of the emergence innovative technologies, more sophisticated diagnostics methods, opportunities for intensive therapy, antibacterial prophylaxis, surgical methods treatment involving minimally invasive surgery, does not solve problem high overall mortality in severe acute pancreatitis at this time. This indicator last ten years remains a level (10-30%), and case inflammatory forms pancreatitis, reaches 85%. Traditional laboratory criteria diagnosis pancreatic necrosis may involve leukocytosis with destruction leukocyte formula appearance myelocytes metamylocytes it; improvement index intoxication; nuclear destruction; blood glucose growth; growth urea; neutrophil-lymphocytic coefficient; change endogenous creatinine clearance; transaminases. enzymes have greatest value gastrointestinal diagnostic plan. determining α-amylase activity is sensitive valuable criterion control over effectiveness treatment. Also, talking about it worth noting acute-phase proteins. increase proteins inflammation compensatory reaction associated ability to inhibit cells released during cause secondary tissue damage by proteolytic enzymes, as well suppress autoimmune aggression. Due this, process body limited autoaggression restrained. purpose study was phase patients varying severity. Materials methods. based on results examination 88 severity who were treated V.T. Zaytsev Institute General Urgent Surgery Academy Medical Sciences Ukraine, Kharkiv, 45 donors (control group). Results discussion. determination serum dynamics destructive carried out. parameters verified before operation after operative dynamics, second dynamics. Markers can simultaneously serve indicators pancreas determine quality performed intervention. ferritin lactofferin markers an proved basis significant their exudates patients. It has been shown that ferroproteins are reliable process, among others, including classical At same time, identification distinguished its explicitness only latent states. Conclusion. detected changes concentration clinical alpha-2-macroglobulin, lactoferrin, C-reactive protein, correlate degree purulent-destructive